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Also, when supplementing to correct an oral contraceptive-induced vitamin depletion, you may be tempted to take large doses

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Cancer 20 , 772780 (2010)

For instance, curcumin has been shown to upregulate thyroid-specific transcription factors (TTF-1, TTF-2, PAX8) and restore NIS protein expression, thereby overcoming radioiodine (RAI) resistance and enhancing RAI therapy efficacy, offering new perspectives for thyroid cancer treatment (148, 149)